The 2-Minute Rule for PF-07258669
In this article we display that DNL343 reduces ISR activation and neurodegeneration brought on acutely by an optic nerve crush (ONC) injuries or chronically by a germline eIF2B LOF mutation in mice. We also display that DNL343 remedy, initiated at a late phase of disease which much more accurately replicates a scientific dosing paradigm, reversed t